更新更正-波士顿新建研发中心招聘基因/细胞治疗/抗体研发及管理团队

吴红岩医药荐客 2022-01-04

Ø 目前美国研发中心正在建设阶段，主要是以大分子创新药物早期研发为主（基因治疗\细胞治疗\抗体类药物）

Ø 预计今年6月份建造完成，年底前研发团队可以入驻。

Ø 新招募的研发团队暂时在租借的地方办公

Ø 提供签证身份

Ø 研发中心地点：红线地铁附近（ALWIFE）

职位目录：

1 创新药研发副总裁（波士顿创新中心负责人）

2 Director or above, Antibody Discovery

3 Director or above, Cell Therapy

4 Director or above, Gene Therapy

5 Sr. Scientist/Principle Scientist, Gene Therapy

6 Sr. Scientist/Principle Scientist, Cell Therapy

7 Sr. Scientist/Principle Scientist, Antibody Discovery

8 VP of International BD

9 BD Director

10 Environmental, Health and Safety Specialist (EHS Specialist)

11研发中心IT 运维专员（IT administrator）

12 Sr.or Principal scientist, Bispecific Antibody Engineering and Development

13 International Pharmaceuticals QA Director/SD

14 Research Analyst,Target Biology

详细介绍：

1 创新药研发副总裁（波士顿创新中心负责人）

Responsibilities:

1. Take overall responsibility for the company's innovative drug R&D management, lead the team in setting up new products, supervise, manage and guide the progress and quality of innovative drug R&D projects, and ensure that R&D work is completed on time;

2. Formulate medium and long-term strategies and development plans for the company's innovative drug research and development based on the development trend of the industry and enterprises ;

3. In accordance with the development direction and policies of the pharmaceutical industry, formulate and implement decision-making for R&D projects;

4. Be responsible for the research on difficult problems in the process of innovative drug development and coordination among related organizations and departments.

任职要求

1. Ph.D. degree in pharmaceutical related professions, more than 10 years experience in pharmaceutical R&D, rich experience in R&D team management, and priority in large pharmaceutical companies, MNCs or overseas working experience;

2.Outstanding insights on pharmaceutical policies and excellent information research and analysis capabilities. Determine the next step of R&D priorities based on the analysis results.

3.Carry out the selection, establishment, development and application of new projects, organize and promote the development, implementation and management of new drug R&D projects, and formulate schedules for new drug R&D projects.

2 Director or above, Antibody Discovery

Responsibilities:

1. Establish and drive the R&D strategy of therapeutic antibody; lead the research team to deliver high quality drug candidates within timelines.

2. Shape the portfolio and scope of therapeutic antibody pipelines; responsible for the of project plan design, project prioritization and selection, budget planning and management, oversee internal teams and CRO during project execution.

3. Monitor and interpret data from ongoing internal and external studies; assess the medical and scientific implications; make recommendations on “go/no go” decisions or modification of project plans.

4. Accountable for the compliance and direction of key preclinical, clinical, and regulatory documents, including but are not limited to: study protocols, study reports, modeling reports, investigator brochures, patent applications, and IND/IMPDs within agreed timelines and meeting all regulatory requirements.

5. Establish and maintain strong relationships with key opinion leaders relevant to drug candidates and therapeutic areas.

6. Contributes to the identification and evaluation of potential business development opportunities.

7. Manage, mentor, motivate, develop, and retain staff to support assigned activities; conduct performance reviews and drive goal setting and development planning.

8. Ensure adherence to appropriate SOP and GxP guidelines.

Required:

1. A PhD in molecular biology, cellular biology, protein chemistry, immunology, or a related field with advanced knowledge of antibody-based drug discovery and antibody engineering.

2. Hands-on experience in immunization-based, phage display, or other antibody discovery platforms.

3. Superior communication, strategic, and interpersonal skills.

4. A self-starter who can thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment with an entrepreneurial spirit.

5. Pharmaceutical industry R&D work experience.

Preferred:

6. Experience in managing discovery and pre-clinical teams in the biopharmaceutical industry.

7. IND submission experience.

8. Experience managing CRO or external collaborators.

3 Director or above, Cell Therapy

Responsibilities:

1. Establish and drive the R&D strategy of cell therapy; lead the research team to deliver high quality cell therapy drug candidates within timelines.

2. Shape the portfolio and scope of cell therapy pipelines; responsible for the of project plan design, project prioritization and selection, budget planning and management, oversee internal teams and CRO during project execution.

5. Establish and maintain strong relationships with key opinion leaders relevant to drug candidates and therapeutic areas.

6. Contributes to the identification and evaluation of potential business development opportunities.

7. Manage, mentor, motivate, develop, and retain staff to support assigned activities; conduct performance reviews and drive goal setting and development planning.

8. Ensure compliance of cell therapy activities.

Required:

1. A PhD in genetics, virology, cell biology, pharmacology, oncology or a related field.

2. Hands-on experience leading discovery and pre-clinical, CMC programs in CAR-T or TCR-T.

3. Superior communication, strategic, and interpersonal skills

4. A self-starter who can thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment with an entrepreneurial spirit.

Preferred:

5. Experience in managing discovery and pre-clinical teams in the biopharmaceutical industry.

6. IND submission experience.

7. Experience in managing CRO or external collaborators.

4 Director or above, Gene Therapy

Responsibilities:

1. Establish and drive the R&D strategy of gene therapy; lead the research team to deliver high quality gene therapy drug candidates within timelines.

2. Shape the portfolio and scope of gene therapy pipelines; responsible for the of project plan design, project prioritization and selection, budget planning and management, oversee internal teams and CRO during project execution.

5. Establish and maintain strong relationships with key opinion leaders relevant to drug candidates and therapeutic areas.

6. Contributes to the identification and evaluation of potential business development opportunities.

7. Manage, mentor, motivate, develop, and retain staff to support assigned activities; conduct performance reviews and drive goal setting and development planning.

8. Ensure compliance of gene therapy activities.

Required:

1. A PhD in genetics, virology, cell biology, pharmacology or a related field.

2. Hands-on experience leading gene therapy discovery and pre-clinical programs, using platforms such as genome editing/CRISPR, siRNA, mRNA or oncolytic virus.

3. Superior communication, strategic, and interpersonal skills

4. A self-starter who can thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment with an entrepreneurial spirit.

Preferred:

5. Experience in managing discovery and pre-clinical teams in the biopharma industry.

6. IND submission experience.

7. Experience managing CRO or external collaborators.

5 Sr. Scientist/Principle Scientist, Gene Therapy

Responsibilities:

1. Design, optimize, and deliver high quality gene therapy drug candidates; contribute to the development candidate prioritization and selection.

2. Lead gene therapy projects from inception to IND filing.

3. Contribute to developing project plans and manage CRO to execute them.

4. Work collaboratively with internal cross-function teams and external CRO/academic institutes to ensure projects meet timelines, objectives, and budgets.

5. Review data to ensure its accuracy and integrity. Analyze and interpret the data with statistical approaches, and be responsible for timely and effective communication of data, strategy, and results to internal project teams.

6. Participates in preparation of key preclinical, clinical, and regulatory documents, including but are not limited to: study protocols, study reports, modeling reports, investigator brochures, patent applications, and IND/IMPDs within agreed timelines and meeting all regulatory requirements.

7. Identify potential project hurdles, suggest solutions, and contribute to contingency plans.

8. Provide gene therapy expertise on due diligence of business development in-licensing opportunities.

9. Ensure compliance of gene therapy activities.

Required:

1. A PhD in genetics, virology, cell biology, pharmacology or a related field.

2. Hands-on experience in discovery and development of viral based gene therapy products, using platforms such as genome editing/CRISPR, siRNA, mRNA or oncolytic virus.

3. Technical experience in molecular cloning, vector production, vector characterization, and construction of gene therapy vector candidates.

4. Experience designing in vitro and in vivo pharmacology and efficacy studies to test vector candidates.

5. Excellent organizational and time management skills.

6. Excellent verbal and written communication skills for presentations, report writing and day-to-day project team communications.

7. A self-starter who can thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment with an entrepreneurial spirit.

Preferred:

8. Pharmaceutical industry R&D experience in gene therapy.

9. Experience in managing CRO or external collaborators.

6 Sr. Scientist/Principle Scientist, Cell Therapy

参考 Director

7 Sr. Scientist/Principle Scientist, Antibody Discovery

参考 Director

8 VP of International BD

Location: Shanghai, China; USA

Responsibilities:

• Formulate, in partnership with the Simcere Executives, the business and corporate strategy and plans required for pipeline strength and sustainable international growth

• Lead the business development team and influence all necessary key stakeholders to deliver the results aligned with corporate objectives

• Drive the search, identification and assessment of potential business opportunities and deliver robust analyses for decision-making

• Oversee due diligence across multiple functional areas, including research, clinical, regulatory,

manufacturing, finance, intellectual property, and legal

• Lead transaction process including the development and negotiation of legal documents with external commercial partnerships through alliances, joint ventures, and licensing agreements etc.

• Ensure successful integration and further development of external collaboration opportunities through alliance management

• Enhance the international recognition of Simcere and represent and promote Simcere's branding

• Identify potential new growth areas aligned with Simcere's development path

Qualifications and Requirements

• +10 years work experience in Biotechnology/Pharmaceutical industry with at least 10 years experience in business/corporate development leadership position

• Ph.D. in life sciences, biological engineering, chemistry or equivalent

• Demonstrated track record in leading strategic planning and defining executable action plans

• Extensive network covering both industrial contacts as well as scientific, clinical KOLs

• Proven track record of accomplishment in identifying and structuring joint ventures, licensing

agreements, strategic alliances, research partnerships and other corporate collaborations

• Ability to influence and work effectively with varied audiences with different perspectives and

priorities

• Strong leadership, management skills and executive presence, results orientation and creative problem solver

• Deep understanding of Chinese pharmaceutical industry and cross-border collaboration with

demonstrated track record is a strong plus

9 BD Director

Location: Boston, USA or Japan, Europe (London)

Responsibilities:

• Working with Scouts and be responsible for in-depth evaluation and prioritization of external opportunities for collaborations, partnerships, in-licensing, structured transactions and acquisitions

• Lead cross functional due diligence team to assess external products and programs (Executive, R&D, Sales & Marketing, Finance, Legal, Regulatory, Manufacturing, etc.)

• Be responsible for financial modeling of different types of deals, including in-licensing, partnerships, collaborations, acquisitions. Identify key assumptions and risks and incorporate inputs from different teams, R&D, clinical, commercial and legal.

• Be responsible for drafting term sheets for different types of deals and lead business negotiations.

• Be responsible for making proposals and presenting to management team.

• Represent Simcere at industry, investor and partnering conferences; develop and maintain relationship with a wide range of pharmaceutical/biotechnology industry participants.

Qualifications and requirements:

• Bachelor’s degree in science at minimum; MBA, MD, JD, PhD is strongly preferred

• 6+ years’ experience in business development, consulting or investment banking

• Strong analytical skills, knowledge of financial modeling, including DCF, NPV analysis is required

• Familiarity with forecasting methodologies is preferred

• Familiarity with drug development and commercialization is a plus

• Strong communication and presentation skills

• Strong leadership to lead and work with cross functional team

• Flexibility to travel domestically and internationally 20-30%

• Demonstrated ability to work in a complex matrix and cross-cultural environment

• Ability to excel in demanding and fast paced working environment

• Mandarin speaking is a plus

10 Environmental, Health and Safety Specialist (EHS Specialist)

Responsibilities

1. Develop safe working techniques, safety policies, guidelines and procedure

2. Monitor compliance to EHS training and site procedures.

3. Analyze safety metrics and review incidents weekly and monthly to identify incident trends. Communicate trends to leadership.

4. Identify EHS program and training improvement opportunities.

5. Develop, execute, and oversee an effective audit strategy to ensure regulatory and corporate EHS program compliance.

6. Maintain working relationships with Regulatory Agencies; keep current the required training and certifications as required in OSHA and industry procedures as required

7. Audit record keeping practices and system entries to ensure compliance.

8. Oversees department-specific IT systems related to EHS, providing project management to third party vendors when necessary.

9. Deliver on-time and quality projects.

10. As needed, complete hazard assessments, industrial hygiene monitoring, process hazard analysis, life safety reviews, incident investigations, environmental regulatory field analysis, environmental reports and permit applications.

Requirements:

1. BS/BA in safety, environmental, ergonomics or a science field with 2+ years applied professional EHS work experience

2. Hands-on experience in developing and managing EHS program, training and systems.

3. Strong project management techniques and incident investigation skills.

4. Strong analytical skills with demonstrated problem solving ability

5. Ability to develop and implement department goals and strategies.

6. High level of interpersonal skills to work effectively with others

7. Excellent written and verbal communication skills, including comfort interfacing with site leaders.

11研发中心IT 运维专员（IT administrator）

岗位职责

1. 作为美分办公区域 IT负责人，与集团信息部协作，全面负责美分办公区域的 IT建设与维护工作；

2. 根据业务需求，负责所需 IT 软件系统、网络、服务器等设施的建设；